Ozempic and PregnancyOzempic in pregnancy — not recommended; stop ≥2 months before planned pregnancy; fetal-risk data; what to do if pregnancy occurs on treatment.

Short answer: Ozempic is not recommended in pregnancy. Animal studies showed fetal harm; human data is limited. The FDA label says to stop semaglutide at least 2 months before a planned pregnancy. If pregnancy occurs on treatment, stop and contact your doctor immediately.

What the evidence shows

Animal reproduction studies showed fetal abnormalities and growth effects. Adequate human studies don't exist — the label position is not-recommended, and the 2-month pre-pregnancy washout accounts for the ~5-week clearance time.

Practical guidance

Planning pregnancy — stop ≥2 months before conception attempts
Pregnancy occurs on drug — stop immediately, contact doctor
Diabetes in pregnancy — insulin is the established standard; a doctor switches therapy
Effective contraception during treatment is sensible for women of childbearing age

Ozempic (semaglutide) FDA Prescribing Information, Novo Nordisk, 2024.

STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding et al., NEJM 2021).

SUSTAIN 6 — Semaglutide and Cardiovascular Outcomes in Type 2 Diabetes (Marso et al., NEJM 2016).

American Diabetes Association — Standards of Care in Diabetes — 2026.

NICE Guideline NG28 — Type 2 diabetes in adults: management.

World Health Organization — Diabetes fact sheet.

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